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ANG1005
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Catalog No. T78034Cas No. 1075214-55-9
ANG1005 is a brain-penetrating peptide-agent conjugate comprising a taxane derivative that features three paclitaxel molecules covalently bonded to Angiopep-2. This design facilitates crossing of the blood-brain and blood-cerebrospinal barriers, with subsequent penetration of malignant cells through the low-density lipoprotein receptor-related protein (LRP1) transport system [1] [2] [3].
ANG1005
ANG1005
😃Good
Catalog No. T78034Cas No. 1075214-55-9
ANG1005 is a brain-penetrating peptide-agent conjugate comprising a taxane derivative that features three paclitaxel molecules covalently bonded to Angiopep-2. This design facilitates crossing of the blood-brain and blood-cerebrospinal barriers, with subsequent penetration of malignant cells through the low-density lipoprotein receptor-related protein (LRP1) transport system [1] [2] [3].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ANG1005 is a brain-penetrating peptide-agent conjugate comprising a taxane derivative that features three paclitaxel molecules covalently bonded to Angiopep-2. This design facilitates crossing of the blood-brain and blood-cerebrospinal barriers, with subsequent penetration of malignant cells through the low-density lipoprotein receptor-related protein (LRP1) transport system [1] [2] [3]. |
| In vivo | ANG1005 has shown a significantly improved brain delivery and therapeutic effect on breast cancer brain metastases [1] compared to free paclitaxel. |
| Molecular Weight | 5127.33 |
| Formula | C256H306N32O81 |
| Cas No. | 1075214-55-9 |
Storage & Solubility Information
| Storage | keep away from moisture | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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