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Angiopep-2 hydrochloride

Name: Angiopep-2 hydrochloride
Brand: TargetMol
SKU: T78016
Price: 98 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T78016

Angiopep-2 hydrochloride is a brain-targeting peptide vector. Conjugating anticancer agents to Angiopep-2 may enhance their therapeutic effect against brain cancer [1].

Angiopep-2 hydrochloride

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Catalog No. T78016

Angiopep-2 hydrochloride is a brain-targeting peptide vector. Conjugating anticancer agents to Angiopep-2 may enhance their therapeutic effect against brain cancer [1].

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	Backorder
50 mg	Inquiry	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Angiopep-2 hydrochloride is a brain-targeting peptide vector. Conjugating anticancer agents to Angiopep-2 may enhance their therapeutic effect against brain cancer [1].
In vitro	Paclitaxel is conjugated with the brain peptide carrier Angiopep-2 hydrochloride, forming a compound called ANG1005. This paclitaxel-Angiopep-2 hydrochloride conjugate, ANG1005, enters the brain to a greater extent and circumvents P-glycoprotein (P-gp) more effectively. ANG1005 exhibits antitumor activity against human cancer cell lines comparable to that of paclitaxel [1].
In vivo	Administration of ANG1005 significantly enhances the survival rates of mice with intracranial implantation of U87 MG glioblastoma or NCI-H460 lung cancer cells [1].

Chemical Properties

Molecular Weight	2337.93
Formula	C₁₀₄H₁₅₀ClN₂₉O₃₁

Storage & Solubility Information

Storage

keep away from moisture | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc