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Anti-inflammatory agent 17

Name: Anti-inflammatory agent 17
Brand: TargetMol
SKU: T61302
Rating: 4.5 (1 reviews)

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Catalog No. T61302Cas No. 2763226-84-0

Anti-inflammatory agent 17 an orally active anti-inflammatory agent, demonstrates potent efficacy in inhibiting the release of IL-6 and TNF-α without causing cytotoxicity in in vitro experiments. Furthermore, in vivo studies confirm its anti-inflammatory activity. Given its attributes, Compound 17 holds promise for investigating Acute lung injury (ALI) [1].

Anti-inflammatory agent 17

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Catalog No. T61302Cas No. 2763226-84-0

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	Anti-inflammatory agent 17 an orally active anti-inflammatory agent, demonstrates potent efficacy in inhibiting the release of IL-6 and TNF-α without causing cytotoxicity in in vitro experiments. Furthermore, in vivo studies confirm its anti-inflammatory activity. Given its attributes, Compound 17 holds promise for investigating Acute lung injury (ALI) [1].
In vitro	Anti-inflammatory agent 17 (compound 5b) (10 μM; 24 h) exhibits no toxicity in J774a.1 cells and, at concentrations of 1.25, 2.5, 5, and 10 μM over 2 hours, inhibits IL-6 (IC50 = 8.254 μM) and TNF-α (IC50 = 2.576 μM) production in a dose-dependent manner [1].
In vivo	The anti-inflammatory agent 17, when administered intragastrically at a dosage of 20 mg/kg, has demonstrated a protective effect against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in C57/BL6 mice [1].

Chemical Properties

Molecular Weight	357.4
Formula	C₂₀H₂₃NO₅
Cas No.	2763226-84-0

Storage & Solubility Information

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc