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Description | Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734, exhibits potent antiviral efficacy. It is primarily utilized in the study of coronavirus and Ebola virus (EBOV). |
In vitro | Anti-virus agent 1 (compound 4i) exhibits antiviral properties against EBOV in various cell lines, including HeLa cells [EC 50 =1845 nM], TERT-immortalized human foreskin microvascular endothelial (HMVEC) cells (ATCC-4025) [EC 50 =367 nM], and human macrophages [EC 50 =297 nM]. It possesses a cytotoxic concentration (CC 50) of 21 μM in MT4 cells (human leukemia T-cell)[1]. |
Alias | Anti-virus agent 1, Remdesivir isopropyl ester analog |
Molecular Weight | 560.504 |
Formula | C24H29N6O8P |
Cas No. | 1911578-83-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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