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Anti-CLU Monoclonal Antibody-AF488
Anti-CLU Monoclonal Antibody-AF488
Anti-CLU Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Catalog No. TMAZ-0178A4
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Anti-CLU Monoclonal Antibody-AF488
Catalog No. TMAZ-0178A4Alias Testosterone-repressed prostate message 2, Sulfated glycoprotein 2, NA1/NA2, Ku70-binding protein 1, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, Clusterin, Apolipoprotein J, Aging-associated gene 4 protein
Anti-CLU Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $55 | 12 days | |
| 50 μg | $95 | 12 days | |
| 100 μg | $140 | 12 days |
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CLU Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
| Alias | Testosterone-repressed prostate message 2, Sulfated glycoprotein 2, NA1/NA2, Ku70-binding protein 1, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, Clusterin, Apolipoprotein J, Aging-associated gene 4 protein |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CLU overexpressed 355F cells with TMAZ-0178A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CLU protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed: 11123922, PubMed: 19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed: 11123922, PubMed: 12176985, PubMed: 17260971, PubMed: 19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed: 12047389, PubMed: 17407782, PubMed: 17412999). Does not require ATP (PubMed: 11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed: 11123922). Does not refold proteins by itself (PubMed: 11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed: 21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed: 2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed: 20068069). Modulates NF-kappa-B transcriptional activity (PubMed: 12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed: 16113678, PubMed: 17689225). Plays a role in the regulation of cell proliferation (PubMed: 19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed: 22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity)|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed: 21567405) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 3 |
| Immunogen | CLU |
| Antigen Species | Human |
| Gene ID | 1191 |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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