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Anti-EFNA1 Monoclonal Antibody-AF647
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Catalog No. TMAZ-0208A6
Alias Tumor necrosis factor alpha-induced protein 4, Immediate early response protein B61, Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1
Anti-EFNA1 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting EFNA1. Anti-EFNA1 Monoclonal Antibody-AF647 can be used in ELISA, FACS.
Anti-EFNA1 Monoclonal Antibody-AF647
Anti-EFNA1 Monoclonal Antibody-AF647
😃Good
Catalog No. TMAZ-0208A6Alias Tumor necrosis factor alpha-induced protein 4, Immediate early response protein B61, Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1
Anti-EFNA1 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting EFNA1. Anti-EFNA1 Monoclonal Antibody-AF647 can be used in ELISA, FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-EFNA1 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting EFNA1. Anti-EFNA1 Monoclonal Antibody-AF647 can be used in ELISA, FACS. |
| Alias | Tumor necrosis factor alpha-induced protein 4, Immediate early response protein B61, Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of EFNA1 overexpressed 436F cells with TMAZ-0208A6, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of EFNA1 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis |
| Conjucates | AF647 |
| Others Formats | Biotin/APC/PE/AF488/AF555 |
| Antibody Types Available | 2 |
| Immunogen | EFNA1 |
| Antigen Species | Human |
| Gene ID | 1942 |
| Uniprot ID | |
| Biology Area | Cytokines |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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