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Anti-NTRK2 Monoclonal Antibody-AF555
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Catalog No. TMAZ-0205A5
Alias Tropomyosin-related kinase B, TrkB tyrosine kinase, Neurotrophic tyrosine kinase receptor type 2, GP145-TrkB, BDNF/NT-3 growth factors receptor
Anti-NTRK2 Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting NTRK2. Anti-NTRK2 Monoclonal Antibody-AF555 can be used in ELISA, FACS.
Anti-NTRK2 Monoclonal Antibody-AF555
Anti-NTRK2 Monoclonal Antibody-AF555
😃Good
Catalog No. TMAZ-0205A5Alias Tropomyosin-related kinase B, TrkB tyrosine kinase, Neurotrophic tyrosine kinase receptor type 2, GP145-TrkB, BDNF/NT-3 growth factors receptor
Anti-NTRK2 Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting NTRK2. Anti-NTRK2 Monoclonal Antibody-AF555 can be used in ELISA, FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $310 | 12 days | |
| 50 μg | $520 | 12 days | |
| 100 μg | $775 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-NTRK2 Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting NTRK2. Anti-NTRK2 Monoclonal Antibody-AF555 can be used in ELISA, FACS. |
| Alias | Tropomyosin-related kinase B, TrkB tyrosine kinase, Neurotrophic tyrosine kinase receptor type 2, GP145-TrkB, BDNF/NT-3 growth factors receptor |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of NTRK2 overexpressed 485F cells with TMAZ-0205A5, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of NTRK2 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed: 15494731, PubMed: 7574684). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed: 15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia |
| Conjucates | AF555 |
| Others Formats | Biotin/APC/PE/AF488/AF647 |
| Antibody Types Available | 1 |
| Immunogen | NTRK2 |
| Antigen Species | Human |
| Gene ID | 4915 |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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