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Anti-TGFBR2 Monoclonal Antibody-AF647
Catalog No. TMAZ-0192A6
Alias Transforming growth factor-beta receptor type II, TGF-beta type II receptor, TGF-beta receptor type-2
Anti-TGFBR2 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
Anti-TGFBR2 Monoclonal Antibody-AF647
Anti-TGFBR2 Monoclonal Antibody-AF647
Catalog No. TMAZ-0192A6Alias Transforming growth factor-beta receptor type II, TGF-beta type II receptor, TGF-beta receptor type-2
Anti-TGFBR2 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TGFBR2 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting TGFBR2. Anti-TGFBR2 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF. |
| Alias | Transforming growth factor-beta receptor type II, TGF-beta type II receptor, TGF-beta receptor type-2 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of TGFBR2 overexpressed 311F cells with TMAZ-0192A6, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of TGFBR2 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways|Has transforming growth factor beta-activated receptor activity|Has transforming growth factor beta-activated receptor activity|Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1 |
| Conjucates | AF647 |
| Others Formats | Biotin/APC/PE/AF488/AF555 |
| Antibody Types Available | 1 |
| Immunogen | TGFBR2 |
| Antigen Species | Human |
| Gene ID | 7048 |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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