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CEP-9722
🥰Excellent
Catalog No. T62196Cas No. 916574-83-9
Alias CK-102, CK102, CEP9722
CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer.
CEP-9722
🥰Excellent
Purity: 99.64%
Catalog No. T62196Alias CK-102, CK102, CEP9722Cas No. 916574-83-9
CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,140 | In Stock | |
| 50 mg | $2,785 | In Stock | |
| 100 mg | $3,520 | In Stock |
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Purity:99.64%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CEP-9722 is an orally active, selective and potent inhibitor of poly (ADP-ribose) polymerase-1 PARP-1 and poly (ADP-ribose) polymerase-12 PARP-2, with anticancer activity, and can be used for the study of ovarian cancer. |
| Targets&IC50 | PARP1:20 nM, PARP2:6 nM |
| In vitro | CEP-9722, the precursor drug of CEP-8983, is a selectively orally active inhibitor of PARP-1 and PARP-2, with IC50s of 20 nM and 6 nM for both, respectively.[2] |
| In vivo | In the RT4 xenograft model, CEP-9722 (100-200 mg/kg/day; oral gavage; once daily; 5 days per week for 4 weeks) showed dose-dependent antitumor effects; 200 mg/kg/day was significantly superior to the control, while 100 mg/kg did not show significantly better efficacy than the control. [1] |
| Alias | CK-102, CK102, CEP9722 |
| Molecular Weight | 418.49 |
| Formula | C24H26N4O3 |
| Cas No. | 916574-83-9 |
| Smiles | O=C1C2=C3C(NC=4C=CC=C(OC)C43)=C5C(=C2C(=O)N1CN6CCN(C)CC6)CCC5 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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