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Antitumor agent-70

Catalog No. T61313 CAS 2454133-88-9

Antitumor agent-70 (compound 8b) is a highly potent multi-targeted kinase inhibitor, particularly targeting c-Kit. It demonstrates remarkable anti-tumor activity and the ability to induce cell apoptosis. This compound also exhibits strong inhibition of multiple myeloma, with an IC 50 value of 0.12 μM. Therefore, Antitumor agent-70 holds great potential as an effective therapy for combating cancer, especially in cases involving c-Kit. [1]

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Antitumor agent-70, CAS 2454133-88-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Antitumor agent-70 (compound 8b), at concentrations ranging from 0 to 50 μM when administered for 24 hours, exhibits potent anti-tumor activity, particularly against the multiple myeloma cell lines RPMI8226 and U266, as well as human umbilical vein endothelial cells (HUVEC), with IC50 values of 0.12 μM, 3.81 μM, and 12.09 μM, respectively [1]. When used at lower concentrations (0 to 0.2 μM) over the same duration, it effectively halts cell cycle progression at the G0/G1 phase in RPMI8226 cells and substantially increases the rate of apoptosis, favoring early over late apoptosis, by triggering the release of reactive oxygen species (ROS) [1]. These findings demonstrate its considerable potential in inhibiting cell proliferation and inducing cell death in cancer cells.

Molecular Weight	358.39
Formula	C21H18N4O2
CAS No.	2454133-88-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Antitumor agent-70 2454133-88-9 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.