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AP219

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Catalog No. T36240Cas No. 779282-36-9

AP39 is a compound used to increase hydrogen sulfide (H2S) levels within mitochondria; it consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219, as a control compound for AP39, contains the triphenylphosphonium scaffold but lacks the H2S-releasing portion.

AP219

AP219

😃Good
Catalog No. T36240Cas No. 779282-36-9
AP39 is a compound used to increase hydrogen sulfide (H2S) levels within mitochondria; it consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219, as a control compound for AP39, contains the triphenylphosphonium scaffold but lacks the H2S-releasing portion.
Pack SizePriceAvailabilityQuantity
1 mgInquiry35 days
5 mgInquiry35 days
10 mgInquiry35 days
25 mgInquiry35 days
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Product Introduction

Bioactivity
Description
AP39 is a compound used to increase hydrogen sulfide (H2S) levels within mitochondria; it consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219, as a control compound for AP39, contains the triphenylphosphonium scaffold but lacks the H2S-releasing portion.
Chemical Properties
Molecular Weight433.551
FormulaC28H34O2P
Cas No.779282-36-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 15 mg/mL (34.6 mM), Sonication is recommended.
DMF: 10 mg/mL (23.07 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.31 mM), Sonication is recommended.
DMSO: 20 mg/mL (46.13 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMF/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.3065 mL11.5327 mL23.0653 mL115.3267 mL
DMF/Ethanol/DMSO
1mg5mg10mg50mg
5 mM0.4613 mL2.3065 mL4.6131 mL23.0653 mL
10 mM0.2307 mL1.1533 mL2.3065 mL11.5327 mL
20 mM0.1153 mL0.5766 mL1.1533 mL5.7663 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

AP-219AP219AP 219
Related Tags: buy AP219 | purchase AP219 | AP219 cost | order AP219 | AP219 chemical structure | AP219 formula | AP219 molecular weight
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