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APC 366 TFA

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Catalog No. T40081Cas No. 2421110-28-1

APC 366 (TFA) is a potent irreversible inhibitor of mast cell tryptase. It is particularly useful in studies related to allergic diseases.

APC 366 TFA

APC 366 TFA

😃Good
Catalog No. T40081Cas No. 2421110-28-1
APC 366 (TFA) is a potent irreversible inhibitor of mast cell tryptase. It is particularly useful in studies related to allergic diseases.
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Product Introduction

Bioactivity
Description
APC 366 (TFA) is a potent irreversible inhibitor of mast cell tryptase. It is particularly useful in studies related to allergic diseases.
In vivo
APC 366 (TFA) (5 mg/kg/0.1 ml; s.c.) effectively mitigates eosinophil recruitment triggered by PAR-2 activating peptide in male BALB/c mice (18–25 g), with subcutaneous administration resulting in a marked reduction in eosinophil recruitment.
Chemical Properties
Molecular Weight554.527
FormulaC24H29F3N6O6
Cas No.2421110-28-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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