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ARL67156 trisodium salt

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Catalog No. T14320Cas No. 1021868-83-6

ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt is an inhibitor of ecto-ATPase.

ARL67156 trisodium salt

ARL67156 trisodium salt

😃Good
Catalog No. T14320Cas No. 1021868-83-6
ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt is an inhibitor of ecto-ATPase.
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10 mg$75535 days
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Product Introduction

Bioactivity
Description
ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt is an inhibitor of ecto-ATPase.
Targets&IC50
NTPDase3:18 μM(ki), NPP1:12 μM(ki), NTPDase1:(ki)11 μM
In vitro
ARL67156 does not significantly inhibit the activity of NTPDase2, NTPDase8, NPP3, and ecto-5′-nucleotidase (CD73), yet it diminishes their activity [1]. In addition, the trisodium salt form of ARL67156 effectively impedes UTP breakdown in superior cervical ganglion cells and enhances contractions triggered by this nucleotide in isolated rat tail artery.
Chemical Properties
Molecular Weight785.05
FormulaC15H21Br2N5Na3O12P3
Cas No.1021868-83-6
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 25 mg/mL (31.72 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.2738 mL6.3690 mL12.7380 mL63.6902 mL
5 mM0.2548 mL1.2738 mL2.5476 mL12.7380 mL
10 mM0.1274 mL0.6369 mL1.2738 mL6.3690 mL
20 mM0.0637 mL0.3185 mL0.6369 mL3.1845 mL

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