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ARL67156 trisodium salt

Name: ARL67156 trisodium salt
Brand: TargetMol
SKU: T14320
Price: 31 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T14320Cas No. 1021868-83-6

ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt is an inhibitor of ecto-ATPase.

ARL67156 trisodium salt

Catalog No. T14320Cas No. 1021868-83-6

ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt is an inhibitor of ecto-ATPase.

Pack Size	Price	Availability	Quantity
10 mg	$755	35 days

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Product Introduction

Bioactivity

Description	ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt is an inhibitor of ecto-ATPase.
Targets&IC50	NTPDase3:18 μM(ki), NPP1:12 μM(ki), NTPDase1:（ki）11 μM
In vitro	ARL67156 does not significantly inhibit the activity of NTPDase2, NTPDase8, NPP3, and ecto-5′-nucleotidase (CD73), yet it diminishes their activity [1]. In addition, the trisodium salt form of ARL67156 effectively impedes UTP breakdown in superior cervical ganglion cells and enhances contractions triggered by this nucleotide in isolated rat tail artery.

Chemical Properties

Molecular Weight	785.05
Formula	C₁₅H₂₁Br₂N₅Na₃O₁₂P₃
Cas No.	1021868-83-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 25 mg/mL (31.72 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.2738 mL	6.3690 mL	12.7380 mL	63.6902 mL
5 mM	0.2548 mL	1.2738 mL	2.5476 mL	12.7380 mL
10 mM	0.1274 mL	0.6369 mL	1.2738 mL	6.3690 mL
20 mM	0.0637 mL	0.3185 mL	0.6369 mL	3.1845 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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