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Arterolane

Name: Arterolane
Brand: TargetMol
SKU: T14325
Price: 35 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T14325Cas No. 664338-39-0

Alias RBx 11160, OZ 277

Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.

Arterolane

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Catalog No. T14325Alias RBx 11160, OZ 277Cas No. 664338-39-0

Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.

Pack Size	Price	Availability
5 mg	$347	10-14 weeks
25 mg	$987	10-14 weeks
50 mg	$1,360	10-14 weeks
100 mg	$2,190	10-14 weeks
1 mL x 10 mM (in DMSO)	$346	10-14 weeks

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Product Introduction

Bioactivity

Description	Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.
Targets&IC50	P. falciparum (Ro73):1.1 nM, P. falciparum (W2):1.1 nM
In vitro	Arterolane (also known as Trioxolane 7; OZ277; RBx-11160) exhibits inhibitory effects on a variety of Plasmodium falciparum strains, demonstrating IC50 values as follows: 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL against P. falciparum strains K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20 respectively. Furthermore, this antimalarial agent shows potent efficacy with IC50s of 1.1 nM (0.43 ng/mL) against both P. falciparum strains Ro73 and W2.
Alias	RBx 11160, OZ 277

Chemical Properties

Molecular Weight	392.53
Formula	C₂₂H₃₆N₂O₄
Cas No.	664338-39-0
Relative Density.	1.202 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (254.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5476 mL	12.7379 mL	25.4758 mL	127.3788 mL
5 mM	0.5095 mL	2.5476 mL	5.0952 mL	25.4758 mL
10 mM	0.2548 mL	1.2738 mL	2.5476 mL	12.7379 mL
20 mM	0.1274 mL	0.6369 mL	1.2738 mL	6.3689 mL
50 mM	0.0510 mL	0.2548 mL	0.5095 mL	2.5476 mL
100 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2738 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OZ-277ArterolaneOZ277