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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,120 | 8-10 weeks | |
50 mg | $2,780 | 8-10 weeks | |
100 mg | $3,700 | 8-10 weeks |
Description | Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue. |
In vitro | Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen. Arzoxifene exerts a statistically significant inhibition of pS2 and progesterone receptor B mRNA expression. A significant agonistic effect is observed in the antitrypsin mRNA expression. In contrast to estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression. |
In vivo | Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose-dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene prevents loss of bone due to ovariectomy with maximal efficacy observed at 0.1-1 mg/kg/day ( ED50: about 0.01 mg/kg). Arzoxifene antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels (ED50: 0.03 mg/kg/day). |
Alias | SERM 3, LY 353381 HCl |
Molecular Weight | 512.06 |
Formula | C28H30ClNO4S |
Cas No. | 182133-27-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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