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AS-604850
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Catalog No. T22587
AS-604850 is a selective and ATP-competitive PI3Kγ inhibitor (IC50= 2.5 μM). It has over 30-fold selectivity for PI3Kδ and PI3Kβ, and 18-fold selectivity over PI3Kα.
AS-604850
😃Good
Catalog No. T22587
AS-604850 is a selective and ATP-competitive PI3Kγ inhibitor (IC50= 2.5 μM). It has over 30-fold selectivity for PI3Kδ and PI3Kβ, and 18-fold selectivity over PI3Kα.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $225 | Backorder | |
| 10 mg | $396 | Backorder | |
| 25 mg | $864 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AS-604850 is a selective and ATP-competitive PI3Kγ inhibitor (IC50= 2.5 μM). It has over 30-fold selectivity for PI3Kδ and PI3Kβ, and 18-fold selectivity over PI3Kα. |
| In vitro | AS-604850 pretreatment abolished GCDC-induced phosphorylation of Akt by 50% and inhibited apoptosis by reducing GCDC/TCDC/TLC-induced caspase-3 cleavage in rat hepatocytes. In PI3KCG-/-monocytes and THP-1 (human monocytic cell line), AS-604850 inhibited the PKB phosphorylation activated by MCP-1, it also blocked the MCP-1-mediated chemotaxis in a concentration-dependent manner. In RAW264 mouse macrophages, C5a-mediated PKB phosphorylation was inhibited by AS-604850 [1][2]. |
| In vivo | In the thioglycollate-induced peritonitis model that induced multiple chemokines in vivo, oral administration of 10 mg/kg AS-604850 showed a 31% decrease in neutrophil recruitment [1]. |
| Molecular Weight | 285.22 |
| Formula | C11H5F2NO4S |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: Soluble |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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