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ASIC-IN-1

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Catalog No. T61537Cas No. 308088-10-0

ASIC-IN-1 is a potent inhibitor of acid-sensing ion channels, demonstrating an IC50 value of less than 10 μM, and it effectively reduces pain intensity in a dose-dependent manner [1].

ASIC-IN-1

ASIC-IN-1

😃Good
Catalog No. T61537Cas No. 308088-10-0
ASIC-IN-1 is a potent inhibitor of acid-sensing ion channels, demonstrating an IC50 value of less than 10 μM, and it effectively reduces pain intensity in a dose-dependent manner [1].
Pack SizePriceAvailabilityQuantity
25 mg1.444 €6-8 weeks
50 mg1.881 €6-8 weeks
100 mg2.375 €6-8 weeks
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Product Introduction

Bioactivity
Description
ASIC-IN-1 is a potent inhibitor of acid-sensing ion channels, demonstrating an IC50 value of less than 10 μM, and it effectively reduces pain intensity in a dose-dependent manner [1].
In vivo
ASIC-IN-1 (compound A) (50 mg/kg; i.p.) effectively reduces pain in a dose-dependent manner, as evidenced by decreased flinching in male Sprague-Dawley rats (150-180 g) following an intraplantar formalin injection-induced pain, significantly inhibiting the acute tonic pain triggered by formalin application to the paw [1].
Chemical Properties
Molecular Weight375.46
FormulaC23H25N3O2
Cas No.308088-10-0
Storage & Solubility Information
StorageShipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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