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Atrimustine
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Catalog No. T14344Cas No. 75219-46-4
Alias KM2210, Bestrabucil
Atrimustine, a conjugate of chlorambucil and β-estradiol benzoate, possesses antitumor activity.
Atrimustine
😃Good
Catalog No. T14344Alias KM2210, BestrabucilCas No. 75219-46-4
Atrimustine, a conjugate of chlorambucil and β-estradiol benzoate, possesses antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $916 | 6-8 weeks | |
| 50 mg | $1,190 | 6-8 weeks | |
| 100 mg | $1,860 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Atrimustine, a conjugate of chlorambucil and β-estradiol benzoate, possesses antitumor activity. |
| In vitro | Atrimustine (Bestrabucil), a conjugate combining chlorambucil with β-estradiol benzoate, exhibits a high affinity for tumor cells, thereby boosting the antitumor efficacy of chlorambucil[1]. This compound demonstrates concentration-dependent inhibition of growth factor production in Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cancer cell line, across a range of 100 nM to 10 μM. This inhibition is evidenced through a 3H-thymidine uptake assay[2], highlighting Atrimustine's potential in hindering cancer cell proliferation. |
| Alias | KM2210, Bestrabucil |
| Molecular Weight | 720.72 |
| Formula | C41H47Cl2NO6 |
| Cas No. | 75219-46-4 |
| Relative Density. | 1.1424 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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