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ATWLPPRAANLLMAAS

Name: ATWLPPRAANLLMAAS
Brand: TargetMol
SKU: TP2993
Rating: 4.5 (1 reviews)

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Catalog No. TP2993Cas No. 1228447-26-4

ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).

ATWLPPRAANLLMAAS

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Catalog No. TP2993Cas No. 1228447-26-4

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Product Introduction

Bioactivity

Description	ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).
In vitro	ATWLPPRAANLLMAAS (V3) (25-200 μM; 12-24 h) suppresses the proliferation, viability, migration, and invasion of human HCC cells (SMMC-7721, Huh-7) by inhibiting the Ras/Raf/MEK/ERK signaling pathway, though no significant effects were observed in HL-7702 cells.
In vivo	ATWLPPRAANLLMAAS (160-480 μg/kg; s.c.; once daily for 7 days) can significantly inhibit the growth of transplanted mouse sarcoma S180 and H22 liver cancer tumors in a dose-dependent manner. Additionally, ATWLPPRAANLLMAAS (200 μg/kg; s.c.; once daily for 4 weeks) suppresses the growth of human HCC xenograft tumors by downregulating angiogenesis and promoting apoptosis.

Chemical Properties

Molecular Weight	1682.98
Formula	C₇₆H₁₂₃N₂₁O₂₀S
Cas No.	1228447-26-4

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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