Auriculin A, a synthetic atrial natriuretic factor (ANF), exhibits hemodynamic properties by antagonizing renal vasoconstriction in dogs and affects arterial baroreflex regulation of heart rate, systemic blood pressure, and constant flow-perfused hind limb perfusion pressure in rabbits [1] [2].

Auriculin A, administered intravenously at a dose of 0.3 μg/min/kg for 30 minutes, counteracts renal vasoconstriction in canines [1]. At a different dosing regimen—2 μg/kg initially, followed by 0.2 μg/kg/min for 45 minutes, intravenously—Auriculin A affects arterial baroreflex regulation of heart rate, systemic blood pressure, and constant flow-induced perfusion pressure in the hind limbs of rabbits [2].