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Avenanthramide-C methyl ester

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Catalog No. T36198Cas No. 955382-52-2

Avenanthramide-C methyl ester inhibits NF-κB activation by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM), thereby dose-dependently inhibiting the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

Avenanthramide-C methyl ester

Avenanthramide-C methyl ester

😃Good
Catalog No. T36198Cas No. 955382-52-2
Avenanthramide-C methyl ester inhibits NF-κB activation by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM), thereby dose-dependently inhibiting the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.
Pack SizePriceAvailabilityQuantity
500 μg$138 35 days
1 mg$253 35 days
5 mg$1,050 35 days
10 mg$1,830 35 days
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Product Introduction

Bioactivity
Description
Avenanthramide-C methyl ester inhibits NF-κB activation by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM), thereby dose-dependently inhibiting the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.
Chemical Properties
Molecular Weight329.3
FormulaC17H15NO6
Cas No.955382-52-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL (1.52 mM), Sonication is recommended.
DMSO: 20 mg/mL (60.73 mM), Sonication is recommended.
DMF: 20 mg/mL (60.73 mM), Sonication is recommended.
Ethanol: 10 mg/mL (30.37 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.6073 mL3.0367 mL6.0735 mL30.3674 mL
10 mM0.3037 mL1.5184 mL3.0367 mL15.1837 mL
20 mM0.1518 mL0.7592 mL1.5184 mL7.5919 mL
DMSO/DMF
1mg5mg10mg50mg
50 mM0.0607 mL0.3037 mL0.6073 mL3.0367 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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