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AZD0424

AZD0424
AZD0424, an orally active compound characterized as a dual selective Src/Abl kinase inhibitor, exhibits potential antineoplastic activity[1] and promotes apoptosis and cell cycle arrest in lymphoma cells[2].
Catalog No. T14370Cas No. 692054-06-1

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AZD0424

Catalog No. T14370Cas No. 692054-06-1

AZD0424, an orally active compound characterized as a dual selective Src/Abl kinase inhibitor, exhibits potential antineoplastic activity[1] and promotes apoptosis and cell cycle arrest in lymphoma cells[2].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$2,42010-14 weeks
50 mg$3,18010-14 weeks
100 mg$4,30010-14 weeks
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Product Introduction

Bioactivity
Description
AZD0424, an orally active compound characterized as a dual selective Src/Abl kinase inhibitor, exhibits potential antineoplastic activity[1] and promotes apoptosis and cell cycle arrest in lymphoma cells[2].
In vitro
AZD0424 (5 μM; 48 hours) leads to increased G0/G1 cell cycle arrest in DOHH-2 and WSU-NHL cells, whereas the cell cycle progression of the nonsensitive cell lines Raji and Jurkat remains unaffected[2]. AZD0424 (1-5 μM; 24-48 hours) is emerged to be the more effective of the three tested inhibitors (AZM559756, AZD0530 and AZD0424), inducing the highest levels of apoptosis with the lowest concentrations in lymphoma cells[2].
Chemical Properties
Molecular Weight528.99
FormulaC25H29ClN6O5
Cas No.692054-06-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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