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Azido-PEG1-Boc, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Description | Azido-PEG1-Boc, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | PROTACs, composed of two distinct ligands linked together—one binding to an E3 ubiquitin ligase and the other to the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Molecular Weight | 215.2496 |
Formula | C9H17N3O3 |
Cas No. | 1374658-85-1 |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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