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Bavituximab

Bavituximab
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Concentration:6.2 mg/mL
Purity:SDS-PAGE:95% SEC-HPLC:95%
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Bavituximab

Catalog No. T77401Cas No. 648904-28-3
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody against phosphatidylserine (PS) with vascular targeting and immunomodulatory properties. It can reactivate anti-tumor immunity to inhibit tumor growth. Bavituximab has anti-cancer activity and is often used in combination with Paclitaxel and Carboplatin to study non-small cell lung cancer.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$497In Stock
5 mg$1,230In Stock
10 mg$1,990In Stock
25 mg$2,960In Stock
50 mg$3,920In Stock
100 mg$5,380In Stock
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Product Introduction

Bioactivity
Description
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody against phosphatidylserine (PS) with vascular targeting and immunomodulatory properties. It can reactivate anti-tumor immunity to inhibit tumor growth. Bavituximab has anti-cancer activity and is often used in combination with Paclitaxel and Carboplatin to study non-small cell lung cancer.
In vitro
Bavituximab binds to exposed phosphatidylserine (PS) molecules through the serum protein β2-glycoprotein 1 (β2GP1)[1].
Bavituximab induces antibody-dependent cellular cytotoxicity by binding to PS, leading to the destruction of tumor vessels[1].
Bavituximab (10 μg/mL; 48 h) binds to exposed phosphatidylserine (PS) induced by 10 μM Sorafenib in HUVEC and bEnd.3 cells[2].
In vivo
Sorafenib induces exposure of anionic phospholipids in a mouse tumor model. Bavituximab (100 μg/mouse; i.v.; single dose; administered 48 h after Sorafenib treatment) detects phosphatidylserine exposure in vivo[2].
AliasAnti-PS MAb 3G4
Chemical Properties
Cas No.648904-28-3
Storage & Solubility Information
Storagestore at low temperature store at -80°C

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