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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | 35 days | |
5 mg | $423 | 35 days | |
10 mg | $775 | 35 days | |
25 mg | $1,400 | 35 days |
Description | BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma. |
Molecular Weight | 426.86 |
Formula | C20H19ClN6O3 |
Cas No. | 1615197-10-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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