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BCAT-IN-1
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Catalog No. T40218Cas No. 2581243-32-3
BCAT-IN-1 is a potent, selective, and orally active inhibitor of BCATm, with a pIC50 of 7.3, exhibiting 100-fold greater selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 is suitable for metabolic disease research [1].
BCAT-IN-1
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Catalog No. T40218Cas No. 2581243-32-3
BCAT-IN-1 is a potent, selective, and orally active inhibitor of BCATm, with a pIC50 of 7.3, exhibiting 100-fold greater selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 is suitable for metabolic disease research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $235 | 6-8 weeks | |
| 25 mg | $1,530 | 6-8 weeks | |
| 50 mg | $1,990 | 6-8 weeks | |
| 100 mg | $2,980 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BCAT-IN-1 is a potent, selective, and orally active inhibitor of BCATm, with a pIC50 of 7.3, exhibiting 100-fold greater selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 is suitable for metabolic disease research [1]. |
| In vitro | BCAT-IN-1 (compound 8b) inhibits human BCATm with a pIC50 of 7.0 and mouse BCATm in a cellular assay with a pIC50 of 5.9 [1]. |
| In vivo | BCAT-IN-1 (compound 8b), administered orally at doses ranging from 30 to 300 mg/kg, elevates c BCAA levels in an acute mouse model for an extended period [1]. At a lower dose of 5 mg/kg via oral route, BCAT-IN-1 demonstrates an oral bioavailability (F=28%) and a peak concentration (C max) of 1648 ng/mL in mice [1]. When given intravenously at 1 mg/kg, it shows a half-life (t 1/2 =9.2 hours) and a clearance rate (Cl=4.0 mL/min/kg) in mice [1]. |
| Molecular Weight | 538.46 |
| Formula | C25H24BrN5O2S |
| Cas No. | 2581243-32-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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