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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Bcl-2-IN-11 (compound 6) is a potent and selective inhibitor of Bcl-2 activity, exhibiting an IC50 of 0.9 nM, and demonstrates minimal inhibition against Bcl-xl (IC50 > 1000 nM). This compound is utilized in researching various cancers linked to the overexpression of Bcl-2 family proteins, primarily malignant hematologic conditions such as acute lymphoid leukemia. Importantly, Bcl-2-IN-11 minimizes the risk of toxic side effects, including thrombocytopenia [1], by sparing Bcl-xl. |
In vitro | Bcl-2-IN-11 (compound 6) inhibits the proliferation of RS4;11 acute lymphoblastic cells with an IC50 value of 2.37 nM [1]. |
Molecular Weight | 902.43 |
Formula | C45H49ClFN7O8S |
Cas No. | 2760536-88-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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