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Description | Benzyl-PEG2-CH2COOH is a PEG-based linker for PROTACs (Proteolysis Targeting Chimeras) that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two distinct ligands linked together: one binds to an E3 ubiquitin ligase, and the other binds to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Alias | Benzyl-PEG2-CH2COOH |
Molecular Weight | 254.28 |
Formula | C13H18O5 |
Cas No. | 91842-53-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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