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BF-168
😃Good
Catalog No. T10529Cas No. 634911-47-0
BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
BF-168
😃Good
Catalog No. T10529Cas No. 634911-47-0
BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $376 | 10-14 weeks | |
| 25 mg | $1,140 | 10-14 weeks | |
| 50 mg | $1,490 | 10-14 weeks | |
| 100 mg | $2,360 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42). |
| Targets&IC50 | β-Amyloid (1–42):ki： 6.4 nM |
| In vitro | BF-168 is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques. |
| In vivo | Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice results in specific in vivo labeling of both compact and diffuse amyloid deposits in the brain. Additionally, 18F-radiolabeled BF-168 demonstrates significant initial brain uptake (3.9% injected dose/gm at 2 min post-injection) and rapid clearance (t1/2=24.7 min) after intravenous administration in normal mice. |
| Molecular Weight | 312.34 |
| Formula | C18H17FN2O2 |
| Cas No. | 634911-47-0 |
| Relative Density. | 1.258 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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