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BI-2545
🥰Excellent
Catalog No. T14560Cas No. 2162961-71-7
BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.
BI-2545
🥰Excellent
Catalog No. T14560Cas No. 2162961-71-7
BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.
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Product Introduction
Bioactivity
Chemical Properties
| Description | BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively. |
| Targets&IC50 | C50: 2.2 nM, ATX (human):3.4 nM, ATX (rat): |
| In vitro | BI-2545 demonstrates strong potency with IC50 values of 29 nM in the LPA and 96 nM in the rat whole blood assay, respectively[1]. |
| In vivo | BI-2545 (10 mg/kg; p.o.) demonstrates high and sustained in vivo efficacy in reducing LPAs[1], with a half-life of t1/2=3.4 hours[1]. |
| Molecular Weight | 527.42 |
| Formula | C23H19F6N5O3 |
| Cas No. | 2162961-71-7 |
| Relative Density. | 1.513 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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