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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $88 | 35 days | |
5 mg | $358 | 35 days | |
10 mg | $673 | 35 days |
Description | Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), specifically inhibiting it in a dose-dependent manner while exhibiting minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. At 40 μM, Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells and prevents the assembly of a contractile ring during cell division in Drosophila S2 cells, but it does not affect ring ingression, indicating that Aurora B kinase activity is not required for that process. |
Molecular Weight | 291.71 |
Formula | C13H11ClFN5 |
Cas No. | 220088-42-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Chloroform: Slightly soluble DMSO: Slightly soluble |
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