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Biricodar
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Catalog No. T14616Cas No. 159997-94-1
Alias VX-710
Biricodar is a P-glycoprotein and MRP-1 modulator.
Biricodar
😃Good
Catalog No. T14616Alias VX-710Cas No. 159997-94-1
Biricodar is a P-glycoprotein and MRP-1 modulator.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Biricodar is a P-glycoprotein and MRP-1 modulator. |
| In vitro | Biricodar demonstrates activity against P-glycoprotein (Pgp) and MRP-1 by increasing drug uptake and retention, reversing drug resistance mediated by wild-type BCRP (BCRPR482), and enhancing uptake, retention, and cytotoxicity in HL60/Adr (MRP-1) and 8226/MR20 cells (BCRP(R482)), while having minimal effect on MCF7 AdVP3000 cells (BCRP(R482T))[1]. It effectively inhibits photoaffinity labeling of P-glycoprotein by [3H]azidopine or [125I]iodoaryl azido-prazosin, with EC50 values of 0.75 and 0.55 μM[3]. In 8226/Dox6 cells (Pgp), biricodar enhances mitoxantrone and daunorubicin uptake by 55% and 100%, respectively, retention by 100% and 60%, respectively, and cytotoxicity by 3.1- and 6.9-fold, respectively. VX-710, a non-macrocyclic pipecolinate derivative that binds the FK506 receptor protein, has been shown to restore sensitivity in a range of multidrug-resistant cells, including myeloma, melanoma, carcinoma, and leukemia[2]. |
| Alias | VX-710 |
| Molecular Weight | 603.71 |
| Formula | C34H41N3O7 |
| Cas No. | 159997-94-1 |
| Relative Density. | 1.195 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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