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Bis-propargyl-PEG13 is a PEG-based linker for PROTACs, facilitating the joining of two essential ligands necessary for creating PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.
Pack Size | Price | Availability | Quantity |
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100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | Bis-propargyl-PEG13 is a PEG-based linker for PROTACs, facilitating the joining of two essential ligands necessary for creating PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two distinct ligands linked together: one binds to an E3 ubiquitin ligase, and the other to a target protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 666.79 |
Formula | C32H58O14 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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