Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $987 | 6-8 weeks | |
50 mg | $1,360 | 6-8 weeks | |
100 mg | $1,990 | 6-8 weeks |
Description | BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
Targets&IC50 | M. tuberculosis (strain H37Rv):(MIC50) 0.12 μM |
In vivo | BM635 has potent MIC (0.12 μM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity (ED99: 49 mg/Kg; IC95%: 43–54 mg/Kg) [1]. The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax: 1.62 μM) and a moderate bioavailability (46%) [2]. |
Molecular Weight | 392.51 |
Formula | C25H29FN2O |
Cas No. | 1493762-74-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 31 mg/mL (78.98 mM), Sonication and heating are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.