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BMS-248360

Name: BMS-248360
Brand: TargetMol
SKU: T14672
Price: 41 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T14672Cas No. 254737-87-6

BMS-248360 is a potent, orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor, with Kis of 10 nM and 1.9 nM for hAT1 and hETA receptors, respectively. BMS-248360 demonstrates hypertensive effects[1].

BMS-248360

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Catalog No. T14672Cas No. 254737-87-6

Pack Size	Price	Availability
25 mg	$2,720	10-14 weeks
50 mg	$3,580	10-14 weeks
100 mg	$4,900	10-14 weeks

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Product Introduction

Bioactivity

Description	BMS-248360 is a potent, orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor, with Kis of 10 nM and 1.9 nM for hAT1 and hETA receptors, respectively. BMS-248360 demonstrates hypertensive effects[1].
Targets&IC50	ETA receptor (rat):1.9 nM, AT1 (rat):6.0 nM(ki), ETA receptor (human):1.9 nM(ki), AT1 (human):（ki）10 nM
In vitro	BMS-248360 shows no activity against AT2 and ETB receptor subtypes and it also shows activity against rat AT1 and rat ETA receptor, with Kis of 6.0 nM and 1.9 nM, respectively[1].
In vivo	BMS-248360 is orally bioavailable in rats (%F=38) with excellent oral exposure (Cmax=3.1 μM) and a reasonable elimination profile (T1/2=5.5 hours)[1]. At dosages of 30 and 100 μmol/kg (p.o.), it effectively blocks the hypertensive effects of intravenously administered AII[1].

Chemical Properties

Molecular Weight	659.84
Formula	C₃₆H₄₅N₅O₅S
Cas No.	254737-87-6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

BMS-248360BMS 248360BMS248360