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Atigotatug (BMS-986012) is a humanized antibody targeting fucosylated GM1 ganglioside, used in lung cancer research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $483 | In Stock | |
10 mg | $692 | In Stock | |
25 mg | $1,080 | In Stock | |
50 mg | $1,490 | In Stock |
Description | Atigotatug (BMS-986012) is a humanized antibody targeting fucosylated GM1 ganglioside, used in lung cancer research. |
In vitro | Atigotatug binds to SCLC cell line specific and dose-dependent with EC50 ranges of 6 to 132 nmol/L, respectively. Atigotatug specifically binds FucGM1 with high affinity and acts as an IgG1 mAb, avoiding the need for T cell-dependent class switching. [1] |
In vivo | Atigotatug (0.01 to 3 mg/kg) showed antitumor activity in human SCLC tumor xenotransplantation and PDX models. [1] |
Alias | BMS-986012, BMS986012 |
Molecular Weight | 145.5 |
Smiles | #N/A |
Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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