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Boc-MLF TFA (67247-12-5 free base)

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Boc-MLF TFA (67247-12-5 free base)

Catalog No. T10581

Boc-MLF (TFA) is a specific antagonist of formyl peptide receptor (FPR) and also inhibits signaling through FPRL1 at higher concentrations.

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Pack Size	Price	Availability
5 mg	$91	Backorder
10 mg	$126	Backorder
50 mg	$311	Backorder
100 mg	Inquiry	Backorder
200 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$124	Backorder

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Product Introduction

Bioactivity

Description	Boc-MLF (TFA) is a specific antagonist of formyl peptide receptor (FPR) and also inhibits signaling through FPRL1 at higher concentrations.
In vitro	Boc-MLF inhibits superoxide production induced by FPR agonist fMLF (EC50: 630 nM in neutrophils). Boc-MLF (25 μM) blocks FPRL1-agonist serum amyloid A (SAA) induced calcium response.
Alias	Boc-Met-Leu-Phe-OH (TFA), Boc-MLF TFA

Chemical Properties

Molecular Weight	623.68
Formula	C27H40F3N3O8S
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (240.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6034 mL	8.0169 mL	16.0339 mL	80.1693 mL
5 mM	0.3207 mL	1.6034 mL	3.2068 mL	16.0339 mL
10 mM	0.1603 mL	0.8017 mL	1.6034 mL	8.0169 mL
20 mM	0.0802 mL	0.4008 mL	0.8017 mL	4.0085 mL
50 mM	0.0321 mL	0.1603 mL	0.3207 mL	1.6034 mL
100 mM	0.0160 mL	0.0802 mL	0.1603 mL	0.8017 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

67247-12-5 free baseBocMLF TFA (67247125 free base)67247-12-5Boc MLF TFA (67247 12 5 free base)Boc-Met-Leu-Phe-OH

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