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Boc-NH-PEG5-propargyl

Name: Boc-NH-PEG5-propargyl
Brand: TargetMol
SKU: T14749
Price: 346 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T14749Cas No. 2062663-67-4

Boc-NH-PEG5-propargyl is a PEG-based linker for PROTACs, facilitating the binding of two essential ligands necessary for PROTAC formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-NH-PEG5-propargyl

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Catalog No. T14749Cas No. 2062663-67-4

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Product Introduction

Bioactivity

Description	Boc-NH-PEG5-propargyl is a PEG-based linker for PROTACs, facilitating the binding of two essential ligands necessary for PROTAC formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro	PROTACs feature two distinct ligands linked together: one targets an E3 ubiquitin ligase, while the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	375.46
Formula	C₁₈H₃₃NO₇
Cas No.	2062663-67-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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