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BPH-1358 free base

Name: BPH-1358 free base
Brand: TargetMol
SKU: T10586
Rating: 4.5 (1 reviews)

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Catalog No. T10586Cas No. 801985-13-7

Alias NSC50460 free base

BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).

BPH-1358 free base

😃Good

Catalog No. T10586Alias NSC50460 free baseCas No. 801985-13-7

Pack Size	Price	Availability
25 mg	$1,520	1-2 weeks
50 mg	$1,980	1-2 weeks
100 mg	$2,500	1-2 weeks

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Product Introduction

Bioactivity

Description	BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).
Targets&IC50	Bisphosphonate farnesyl diphosphate synthase (human):1.8 μM
In vitro	BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) and S. aureus UPPS (SaUPPS) with an IC50 of 110 nM and EC50s of 300 nM and 290 nM, respectively, against E. coli and S. aureus [1].
In vivo	In an i.p. infection model with an MRSA strain, BPH-1358 is active against S. aureus (20/20 mice survived) [1].
Alias	NSC50460 free base

Chemical Properties

Molecular Weight	528.6
Formula	C₃₂H₂₈N₆O₂
Cas No.	801985-13-7
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NSC-50460NSC50460NSC 50460human bisphosphonate farnesyl diphosphate synthaseBPH-1358 free baseBPH1358 free baseBPH-1358BPH1358BPH 1358 free baseBPH 1358