BPK-21

BPK-21 is an active acrylamide compound that effectively suppresses T cell activation by blocking the function of ERCC3, a helicase enzyme. BPK-21 specifically targets C342 within the ERCC3 helicase.

Catalog No. T39828Cas No. 2305052-77-9

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BPK-21

Catalog No. T39828Cas No. 2305052-77-9

BPK-21 is an active acrylamide compound that effectively suppresses T cell activation by blocking the function of ERCC3, a helicase enzyme. BPK-21 specifically targets C342 within the ERCC3 helicase.

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Product Introduction

Bioactivity

Description	BPK-21 is an active acrylamide compound that effectively suppresses T cell activation by blocking the function of ERCC3, a helicase enzyme. BPK-21 specifically targets C342 within the ERCC3 helicase.
In vitro	BPK-21 (20 μM) significantly impairs T-cell activation[1], likely by inhibiting ERCC3 function and potentially affecting mechanisms downstream or independent of pathways activating NFAT and NF-kB[1].

Chemical Properties

Molecular Weight	466.28
Formula	C₂₃H₁₆Cl₂F₃NO₂
Cas No.	2305052-77-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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Keywords

BPK 21BPK21BPK-21