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BPN-15477

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Catalog No. T60412Cas No. 1971086-99-3

BPN-15477 is a splicing modulator compound (SMC) that restores the correct splicing of ELP1 exon 20. It can be used for frontotemporal dementia research. BPN-15477 corrects the splicing of the ELP1 transcript which significantly increases the level of functional protein in vivo in all tissues, including the brain [1].

BPN-15477

BPN-15477

😃Good
Catalog No. T60412Cas No. 1971086-99-3
BPN-15477 is a splicing modulator compound (SMC) that restores the correct splicing of ELP1 exon 20. It can be used for frontotemporal dementia research. BPN-15477 corrects the splicing of the ELP1 transcript which significantly increases the level of functional protein in vivo in all tissues, including the brain [1].
Pack SizePriceAvailabilityQuantity
2 mg55 €5 days
1 mL x 10 mM (in DMSO)93 €5 days
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Product Introduction

Bioactivity
Description
BPN-15477 is a splicing modulator compound (SMC) that restores the correct splicing of ELP1 exon 20. It can be used for frontotemporal dementia research. BPN-15477 corrects the splicing of the ELP1 transcript which significantly increases the level of functional protein in vivo in all tissues, including the brain [1].
Chemical Properties
Molecular Weight259.69
FormulaC12H10ClN5
Cas No.1971086-99-3
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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