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Bradanicline

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Catalog No. T61348Cas No. 639489-84-2

Bradanicline is a potent and highly selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 17 nM and a Ki of 1.4 nM for the human α7 nAChR. It is primarily employed in research pertaining to cognitive disorders [1] [2].

Bradanicline

Bradanicline

😃Good
Catalog No. T61348Cas No. 639489-84-2
Bradanicline is a potent and highly selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 17 nM and a Ki of 1.4 nM for the human α7 nAChR. It is primarily employed in research pertaining to cognitive disorders [1] [2].
Pack SizePriceAvailabilityQuantity
25 mg$1,0806-8 weeks
50 mg$1,4106-8 weeks
100 mg$2,1106-8 weeks
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Product Introduction

Bioactivity
Description
Bradanicline is a potent and highly selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 17 nM and a Ki of 1.4 nM for the human α7 nAChR. It is primarily employed in research pertaining to cognitive disorders [1] [2].
In vitro
Bradanicline demonstrates a significant distinction, with over a thousand-fold difference in affinity towards α7 and α4β2 receptor subtypes, without any observable impact on muscle or ganglionic nicotinic receptor subtypes. This indicates a pronounced selectivity for the central nervous system as opposed to the peripheral nervous system [1].
In vivo
Bradanicline (0.1-1 mg/kg) effectively mitigates positive and negative symptoms, along with cognitive impairments, related to schizophrenia in animal models [2].
Chemical Properties
Molecular Weight361.44
FormulaC22H23N3O2
Cas No.639489-84-2
Storage & Solubility Information
StorageShipping with blue ice.

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