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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $55 | Backorder | |
5 mg | $244 | Backorder | |
10 mg | $428 | Backorder | |
25 mg | $939 | Backorder |
Description | BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide (Arg)9, it effectively shortens DNA replication tract lengths and diminishes the frequency of homologous repair of camptothecin-induced DNA damage in vitro. Additionally, BRC4wt enhances the efficacy of the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib in inducing cell death in HeLa human cervical cancer and U2OS human osteosarcoma cells, albeit it does not affect non-cancerous hTERT RPE-1, MRC-5, or MCF-10A cells. |
Molecular Weight | 1739.11 |
Formula | C81H139N23O19.XCF3COOH |
Cas No. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | H2O: Soluble |
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