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BRK inhibitor P21d hydrochloride
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Catalog No. T39772Cas No. 2250025-98-8
Alias BRK inhibitor P21d hydrochloride
BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM, and effectively suppresses p-SAM68 with an IC50 of 52 nM. This compound serves as a valuable tool for evaluating BRK inhibitors' efficacy in xenograft breast tumor models, enabling in vivo activity assessment.
BRK inhibitor P21d hydrochloride
😃Good
Catalog No. T39772Alias BRK inhibitor P21d hydrochlorideCas No. 2250025-98-8
BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM, and effectively suppresses p-SAM68 with an IC50 of 52 nM. This compound serves as a valuable tool for evaluating BRK inhibitors' efficacy in xenograft breast tumor models, enabling in vivo activity assessment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $964 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM, and effectively suppresses p-SAM68 with an IC50 of 52 nM. This compound serves as a valuable tool for evaluating BRK inhibitors' efficacy in xenograft breast tumor models, enabling in vivo activity assessment. |
| Targets&IC50 | Aurora B:>20 μM (IC50), Brk:30 nM (IC50), pSAM68:52 nM (IC50), Lck:>20 μM (IC50) |
| In vitro | BRK inhibitor P21d hydrochloride (compound 21d) inhibits Aurora B and Lck with an IC50 of greater than 20 μM for each target[1]. |
| In vivo | The BRK inhibitor P21d hydrochloride, also known as compound 21d, demonstrates significantly enhanced permeability (CACO-2: 314 nm/s) and pharmacokinetic (PK) properties. When administered orally at a dose of 10 mpk in rats, it exhibits an AUC from 0 to 6 hours of 31.1 μM·h and a concentration of 3.5 μM at the 6-hour mark [1]. |
| Alias | BRK inhibitor P21d hydrochloride |
| Molecular Weight | 483.93 |
| Formula | C23H23ClFN7O2 |
| Cas No. | 2250025-98-8 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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