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BTK inhibitor 10

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Catalog No. T10627Cas No. 2241732-30-7

BTK inhibitor 10 is a potent and orally active compound with potential applications in rheumatoid arthritis treatment.

BTK inhibitor 10

BTK inhibitor 10

😃Good
Catalog No. T10627Cas No. 2241732-30-7
BTK inhibitor 10 is a potent and orally active compound with potential applications in rheumatoid arthritis treatment.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
BTK inhibitor 10 is a potent and orally active compound with potential applications in rheumatoid arthritis treatment.
Targets&IC50
BTK:
In vivo
In CIA mice, BTK inhibitor 10 (oral gavage; 30 mg/kg; 21 days; once daily) has a significant improvement in arthritis symptoms. The damage of each of the 4 paws in mice is divided into 0-4 to calculate the total score of the limbs. BTK030 (21 days; p.o.) reduces the arthritic score to 3.62 while the control group shows a value of 8.33.
Chemical Properties
Molecular Weight441.48
FormulaC25H23N5O3
Cas No.2241732-30-7
Relative Density.1.329 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

BTK inhibitor 10
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