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BTX161

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Catalog No. T60478Cas No. 2052301-24-1

BTX161 is a Thalidomide analogue. BTX161 is a potent CKIα degrader. In human AML cells, BTX161 mediates the CKIα degradation better than Lenalidomide as well as activates DNA damage response (DDR) and p53, and also stabilizes the p53 antagonist MDM2[1].

BTX161

BTX161

😃Good
Catalog No. T60478Cas No. 2052301-24-1
BTX161 is a Thalidomide analogue. BTX161 is a potent CKIα degrader. In human AML cells, BTX161 mediates the CKIα degradation better than Lenalidomide as well as activates DNA damage response (DDR) and p53, and also stabilizes the p53 antagonist MDM2[1].
Pack SizePriceAvailabilityQuantity
25 mg$1,140 6-8 weeks
50 mg$1,490 6-8 weeks
100 mg$2,360 6-8 weeks
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Product Introduction

Bioactivity
Description
BTX161 is a Thalidomide analogue. BTX161 is a potent CKIα degrader. In human AML cells, BTX161 mediates the CKIα degradation better than Lenalidomide as well as activates DNA damage response (DDR) and p53, and also stabilizes the p53 antagonist MDM2[1].
In vitro
BTX161 (25 μM; 4 hours; MV4-11 cells) enhances the expression of Wnt targets such as MYC without altering MDM2 mRNA levels [1]. At a concentration of 10 μM over 6 hours in MV4-11 cells, BTX161 independently increases p53 and MDM2 protein levels. When combined with THZ1, and especially with both THZ1 and CDK9, it further elevates p53 expression and maximizes caspase 3 activation [1].
Chemical Properties
Molecular Weight272.3
FormulaC15H16N2O3
Cas No.2052301-24-1
Storage & Solubility Information
StorageShipping with blue ice.

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