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Bumetanide

Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.

Catalog No. T0108Cas No. 28395-03-1

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Purity:99.9%

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COA HNMR HPLC

Bumetanide

Catalog No. T0108Cas No. 28395-03-1

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Product Introduction

Bioactivity

Description	Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.
Targets&IC50	NKCC1A (human):0.68 μM, NKCC2A (human):4.0 μM
Alias	PF 1593, Ro 10-6338

Chemical Properties

Molecular Weight	364.416
Formula	C₁₇H₂₀N₂O₅S
Cas No.	28395-03-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 36.4 mg/mL (100 mM)

Ethanol: 27.3 mg/mL (75 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7441 mL	13.7206 mL	27.4412 mL	137.2058 mL
5 mM	0.5488 mL	2.7441 mL	5.4882 mL	27.4412 mL
10 mM	0.2744 mL	1.3721 mL	2.7441 mL	13.7206 mL
20 mM	0.1372 mL	0.6860 mL	1.3721 mL	6.8603 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7441 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc