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Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.
Description | Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates. |
Targets&IC50 | NKCC1A (human):0.68 μM, NKCC2A (human):4.0 μM |
Alias | Ro 10-6338, PF 1593 |
Molecular Weight | 364.416 |
Formula | C17H20N2O5S |
Cas No. | 28395-03-1 |
Smiles | CCCCNc1cc(cc(c1Oc1ccccc1)S(N)(=O)=O)C(O)=O |
Relative Density. | 1.2812 g/cm3 (Estimated) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 36.4 mg/mL (100 mM) Ethanol: 27.3 mg/mL (75 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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