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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 8-10 weeks | |
50 mg | $1,980 | 8-10 weeks | |
100 mg | $2,500 | 8-10 weeks |
Description | Bumetanide sodium is a potent loop diuretic that acts as a blocker for the sodium-potassium-chloride cotransporter (NKCC). It selectively inhibits NKCC1 and NKCC2, with IC50 values of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively [1] [2]. |
In vitro | Bumetanide sodium effectively inhibits the major human splice variants of NKCCs, specifically hNKCC1A and hNKCC2A. It demonstrates dose-dependent inhibition of ^86Rb^+ uptake in NKCC1A-expressing oocytes, ranging from 0.03 to 100 μM over 5 minutes. Additionally, Bumetanide sodium targets the NKCC2 isoform B in HEK-293 cells, achieving an IC50 value of 0.54 μM. |
In vivo | Bumetanide sodium (7.6-30.4 mg/kg; i.v.) reduces the decline in apparent diffusion coefficients (ADC) ratios in the cortex and striatum by 40-67%, indicating a decrease in edema formation [3]. Additionally, it decreases infarct size [3]. It exhibits varying half-lives—21.4 min, 53.8 min, and 137 min—after intravenous doses of 2 mg/kg, 8 mg/kg, and 20 mg/kg, respectively, in rats [4]. |
Molecular Weight | 386.4 |
Formula | C17H19N2NaO5S |
Cas No. | 28434-74-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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