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BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN, a multifunctional secreted glycoprotein, and SORT1, a neuronal receptor for PGRN.BVFP is able to block PGRN-SORT1 binding, restore extracellular levels of PGRN , inhibits SORT1-mediated rPGRN endocytosis, and has therapeutic potential for frontotemporal lobe dementia (FTLD-TDP).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $176 | In Stock | |
5 mg | $439 | In Stock | |
10 mg | $619 | In Stock | |
25 mg | $1,090 | In Stock | |
50 mg | $1,670 | In Stock | |
100 mg | $1,780 | In Stock | |
200 mg | $1,930 | In Stock | |
1 mL x 10 mM (in DMSO) | $485 | In Stock |
Description | BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN, a multifunctional secreted glycoprotein, and SORT1, a neuronal receptor for PGRN.BVFP is able to block PGRN-SORT1 binding, restore extracellular levels of PGRN , inhibits SORT1-mediated rPGRN endocytosis, and has therapeutic potential for frontotemporal lobe dementia (FTLD-TDP). |
Molecular Weight | 345.12 |
Formula | C13H8BrF3N2O |
Cas No. | 357158-20-4 |
Smiles | O=C1N=C(C=CC=2C=CC=C(Br)C2)C=C(N1)C(F)(F)F |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40.00 mg/mL (115.90 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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