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BVFP

🥰Excellent
Catalog No. T79105Cas No. 357158-20-4

BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN, a multifunctional secreted glycoprotein, and SORT1, a neuronal receptor for PGRN.BVFP is able to block PGRN-SORT1 binding, restore extracellular levels of PGRN , inhibits SORT1-mediated rPGRN endocytosis, and has therapeutic potential for frontotemporal lobe dementia (FTLD-TDP).

BVFP

BVFP

🥰Excellent
Purity: 98.74%
Catalog No. T79105Cas No. 357158-20-4
BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN, a multifunctional secreted glycoprotein, and SORT1, a neuronal receptor for PGRN.BVFP is able to block PGRN-SORT1 binding, restore extracellular levels of PGRN , inhibits SORT1-mediated rPGRN endocytosis, and has therapeutic potential for frontotemporal lobe dementia (FTLD-TDP).
Pack SizePriceAvailabilityQuantity
1 mg$176 In Stock
5 mg$439 In Stock
10 mg$619 In Stock
25 mg$1,090 In Stock
50 mg$1,670 In Stock
100 mg$1,780 In Stock
200 mg$1,930 In Stock
1 mL x 10 mM (in DMSO)$485 In Stock
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Purity:98.74%
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Product Introduction

Bioactivity
Description
BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN, a multifunctional secreted glycoprotein, and SORT1, a neuronal receptor for PGRN.BVFP is able to block PGRN-SORT1 binding, restore extracellular levels of PGRN , inhibits SORT1-mediated rPGRN endocytosis, and has therapeutic potential for frontotemporal lobe dementia (FTLD-TDP).
Chemical Properties
Molecular Weight345.12
FormulaC13H8BrF3N2O
Cas No.357158-20-4
SmilesO=C1N=C(C=CC=2C=CC=C(Br)C2)C=C(N1)C(F)(F)F
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40.00 mg/mL (115.90 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8975 mL14.4877 mL28.9754 mL144.8771 mL
5 mM0.5795 mL2.8975 mL5.7951 mL28.9754 mL
10 mM0.2898 mL1.4488 mL2.8975 mL14.4877 mL
20 mM0.1449 mL0.7244 mL1.4488 mL7.2439 mL
50 mM0.0580 mL0.2898 mL0.5795 mL2.8975 mL
100 mM0.0290 mL0.1449 mL0.2898 mL1.4488 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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