Shopping Cart
- Remove All
Your shopping cart is currently empty
AF38469
Catalog No. TQ0086Cas No. 1531634-31-7
Alias AF-38469
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
AF38469
Catalog No. TQ0086Alias AF-38469Cas No. 1531634-31-7
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $107 | In Stock | |
| 5 mg | $228 | In Stock | |
| 10 mg | $372 | In Stock | |
| 25 mg | $629 | In Stock | |
| 50 mg | $896 | In Stock | |
| 100 mg | $1,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $253 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "AF38469"
Meclinertant
SR 48692
T16034146362-70-1In house
Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders.
- $78
Size
QTY
(±)-AC 7954 hydrochloride
T22476477313-09-0
(±)-AC 7954 hydrochloride is a urotensin-II (UT) receptor activator.
- $82
Size
QTY
SB-657510
T12848474960-44-6
SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.
- $75
Size
QTY
SB 611812
T23323345892-71-9
SB 611812 is an antagonist of urotensin-II (UT) and can be used in studies about the treatment of cardiovascular disease.
- $38
Size
QTY
[Lys8, Lys9]-Neurotensin (8-13) acetate
T38807L
[Lys8, Lys9]-Neurotensin (8-13) acetate, a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].
- $89
Size
QTY
Substance P 1-9 aceate
TP1819L
Substance P 1-9 aceate is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.
- $59
Size
QTY
Urantide acetate(669089-53-6 free base)
TP2106L
Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-ind
- $115
Size
QTY
Neurotensin
TP131039379-15-2
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.
- $52
Size
QTY
Kinetensin acetate(103131-69-7 free base)
Kinetensin (human) acetate
TP1116L
Kinetensin acetate(103131-69-7 free base) is isolated from pepsin-treated human plasma. Kinetensin acetate(103131-69-7 free base) is a neurotensin-like peptide.
- $96
Size
QTY
Neurotensin(8-13) 3TFA(60482-95-3(free base))
T7617L2952825-79-3
Neurotensin(8-13) 3TFA is Neurotensin (NT) fragment. Neurotensin(8-13) 3TFA results in a decrease in cell-surface NT1 receptors (NTR1) density.
- $32
Size
QTY
SORT-PGRN interaction inhibitor 1
T9044100957-85-5
SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction, with an IC50 of 2 μM.
- $29
Size
QTY
SBI-553
Cited
T168601849603-72-0
SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM).
- $97
Size
QTY
CitedSelect Batch
Purity:99.18%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM). |
| Targets&IC50 | Sortilin:330 nM |
| In vitro | AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein. |
| Alias | AF-38469 |
| Molecular Weight | 324.25 |
| Formula | C15H11F3N2O3 |
| Cas No. | 1531634-31-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (123.36 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy AF38469 | purchase AF38469 | AF38469 cost | order AF38469 | AF38469 chemical structure | AF38469 in vitro | AF38469 formula | AF38469 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.